Relationship between urinary cadmium and mortality among inhabitants living in a cadmium polluted area in Japan

Toxicol Lett. 1999 Sep 5;108(2-3):321-7. doi: 10.1016/s0378-4274(99)00105-8.


A 15 year follow-up study of 3119 inhabitants living in a cadmium polluted area was conducted to investigate the influence of environmental cadmium exposure on the mortality. The cumulative survival curves of the subjects with urinary cadmium concentration > or = 10 microg/g creatinine was lower than that of the subjects with < 10 microg/g creatinine in the men aged 50-59 and 60-69 years and in the women aged 60-69 and 70-79 years. In the men aged 50-69 years and the all aged women, the cumulative survival curves became lower in proportion to the increase of urinary cadmium concentration, when the subjects were divided into four groups according to the amount of urinary cadmium concentration (< 5, 5-9.9, 10.1-19.9, > or = 20 microg/g creatinine). These results suggested a dose response relationship between cadmium exposure and mortality.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cadmium / urine*
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Mining
  • Mortality*
  • Population Surveillance
  • Survival Rate
  • Water Pollutants, Chemical / urine*


  • Water Pollutants, Chemical
  • Cadmium