Knowledge discovery in gene-expression-microarray data: mining the information output of the genome

Trends Biotechnol. 1999 Nov;17(11):429-36. doi: 10.1016/s0167-7799(99)01359-1.


A key aspect of the genomics revolution is the transformation of large amounts of biological information into an electronic format, leading to an information-based approach to biomedical problems. Large-scale RNA assays and gene-expression-microarray studies, in particular, represent the second wave of the genomics revolution, providing gene-expression data that complement gene-sequence data and help our understanding of the molecular basis of health and disease. They are being applied at several stages in the drug-development process and could ultimately have broad applications in disease diagnosis and patient prognosis.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression
  • Genetic Engineering / trends*
  • Genome, Human*
  • Humans
  • Molecular Biology / trends*