Diphenylhydantoin teratogenicity: ocular manifestations and related deformities

J Pediatr Ophthalmol Strabismus. 1978 May-Jun;15(3):137-40. doi: 10.3928/0191-3913-19780501-04.

Abstract

This patient illustrates a classical case of what many pediatricians call the diphenylhydantoin teratogenic syndrome. It suggests the possibility of an additional ocular finding of retinoschisis and optic nerve abnormalities which could conceivably have a teratogenic basis. The effects of epilepsy and diphenylhydantoin on these formations is discussed.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Drug-Induced / etiology*
  • Blepharoptosis / chemically induced
  • Child
  • Child, Preschool
  • Epilepsy / drug therapy
  • Eye Abnormalities*
  • Female
  • Fingers / abnormalities
  • Hair / abnormalities
  • Humans
  • Hypertelorism / chemically induced
  • Infant
  • Infant, Newborn
  • Male
  • Optic Nerve / abnormalities
  • Phenytoin / adverse effects*
  • Phenytoin / therapeutic use
  • Pregnancy
  • Retinal Detachment / chemically induced
  • Strabismus / chemically induced
  • Toes / abnormalities

Substances

  • Phenytoin