Quality of life in ankylosing spondylitis: validation of the ankylosing spondylitis Arthritis Impact Measurement Scales 2, a modified Arthritis Impact Measurement Scales Questionnaire

Arthritis Care Res. 1999 Jun;12(3):157-62. doi: 10.1002/1529-0131(199906)12:3<157::aid-art2>3.0.co;2-r.


Objective: To develop a questionnaire measuring quality of life in ankylosing spondylitis (AS).

Methods: A focus group technique contributed to the generation of an AS-specific questionnaire using the Arthritis Impact Measurement Scales 2 (AIMS2) (12 dimensions), supplemented with items from the Health Assessment Questionnaire for the Spondylar-thropathies, as well as original new items. Patients from a self-help group provided data to assess the validity (n = 146) and reproducibility (n = 43) of the AS-AIMS2.

Results: The focus group generated a thirteenth dimension including 6 items labeled "spine mobility." Principal component analyses on AS-AIMS2 showed satisfactory dimensionality (74.1% of variance explained), high internal consistency (Cronbach's alpha = 0.78-0.91), significant convergent validity of the new dimension with spine pain and mobility, and good reproducibility in the 13 dimensions and 5 components (intraclass correlation coefficient = 0.7-0.9). The scores in each component of the AS-AIMS2 showed a marked deterioration of quality of life in these young patients.

Conclusions: The disease-specific AS-AIMS2 questionnaire should help improve care management in AS.

MeSH terms

  • Activities of Daily Living
  • Adolescent
  • Adult
  • Aged
  • Factor Analysis, Statistical
  • Female
  • Focus Groups
  • Humans
  • Male
  • Middle Aged
  • Quality of Life*
  • Reproducibility of Results
  • Sickness Impact Profile*
  • Spondylitis, Ankylosing / physiopathology*
  • Spondylitis, Ankylosing / psychology*
  • Surveys and Questionnaires / standards*