Atenolol versus amlodipine versus isosorbide-5-mononitrate on anginal symptoms in syndrome X

Am J Cardiol. 1999 Oct 1;84(7):854-6, A8. doi: 10.1016/s0002-9149(99)00450-6.


The effects of a beta blocker (atenolol), a calcium antagonist (amlodipine), and a nitrate (isosorbide-5-mononitrate) on anginal symptoms in 10 patients with syndrome X were assessed in a crossover, double-blind, randomized trial. Only atenolol was found to significantly improve chest pain episodes, suggesting that it should be the preferred drug when starting pharmacologic treatment of patients with syndrome X.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use*
  • Amlodipine / therapeutic use*
  • Analysis of Variance
  • Atenolol / therapeutic use*
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Humans
  • Isosorbide Dinitrate / therapeutic use*
  • Microvascular Angina / drug therapy*
  • Middle Aged
  • Statistics, Nonparametric
  • Treatment Outcome
  • Vasodilator Agents / therapeutic use*


  • Adrenergic beta-Antagonists
  • Vasodilator Agents
  • Amlodipine
  • Atenolol
  • Isosorbide Dinitrate