Relationship between soluble markers of immune activation and bone turnover in post-menopausal women with rheumatoid arthritis

Rheumatology (Oxford). 1999 Sep;38(9):841-7. doi: 10.1093/rheumatology/38.9.841.


Objective: Regarding interactions between pro-inflammatory cytokines and bone metabolism in rheumatoid arthritis (RA), we investigated the relationship between the serum levels of interleukin (IL)-1beta, IL-6, soluble interleukin-2 receptor (sIL-2r), C-reactive protein (CRP), the vitamin D metabolites 25-hydroxyvitamin D3 (25OHD3) and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], intact parathyroid hormone (iPTH) as well as serum and urinary parameters of bone turnover in 74 post-menopausal women with RA.

Results: SIL-2r correlated negatively with 1,25(OH)2D3 (P < 0.01), whereas IL-6 showed a positive correlation with urinary excretion of deoxypyridinoline collagen cross-links (P < 0.01). 1,25(OH)2D3 (P < 0.01) and iPTH (P < 0.01) were negatively related to CRP, whereas the urinary excretion of pyridinoline (P < 0.01) and deoxypyridinoline (P < 0.01)-collagen cross-links showed a positive correlation with CRP. 1,25(OH)2D3 (P < 0.01) and iPTH (P < 0.05) were positively related to bone alkaline phosphatase as a marker of osteoblast function.

Conclusion: Our data indicate that IL-6 is a critical determinant of increased bone resorption in post-menopausal RA women with high disease activity and that serum levels of 1,25(OH)2D3 are inversely related to T-cell activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aging / immunology
  • Aging / metabolism
  • Arthritis, Rheumatoid / immunology*
  • Arthritis, Rheumatoid / metabolism
  • Bone Resorption / metabolism
  • Bone and Bones / metabolism
  • Calcifediol / metabolism
  • Calcitriol / metabolism
  • Calcium / metabolism
  • Female
  • Humans
  • Interleukin-1 / metabolism
  • Interleukin-6 / metabolism
  • Middle Aged
  • Osteoporosis, Postmenopausal / immunology*
  • Osteoporosis, Postmenopausal / metabolism
  • Parathyroid Hormone / metabolism
  • Receptors, Interleukin-2 / metabolism
  • Serum Albumin / metabolism


  • Interleukin-1
  • Interleukin-6
  • Parathyroid Hormone
  • Receptors, Interleukin-2
  • Serum Albumin
  • Calcitriol
  • Calcifediol
  • Calcium