Severe hyperkalaemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction

J Hum Hypertens. 1999 Oct;13(10):717-20. doi: 10.1038/sj.jhh.1000890.


We report two cases of hyperkalaemia related to the use of the salt substitute 'Lo Salt' in hypertensive patients on treatment with ACE inhibitors. In each case serum potassium returned to the normal range after cessation of the salt substitute. Without vigilance the contribution of the salt substitute to hyperkalaemia would have been overlooked and an ACE inhibitor erroneously withdrawn.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Angiotensin-Converting Enzyme Inhibitors / adverse effects*
  • Blood Pressure / drug effects
  • Diuretics / adverse effects*
  • Drug Interactions
  • Drug Therapy, Combination
  • Electrocardiography / drug effects
  • Humans
  • Hyperkalemia / blood
  • Hyperkalemia / chemically induced*
  • Hypertension / blood
  • Hypertension / drug therapy*
  • Hypertension / physiopathology
  • Male
  • Middle Aged
  • Potassium / blood
  • Potassium, Dietary / adverse effects*


  • Angiotensin-Converting Enzyme Inhibitors
  • Diuretics
  • Potassium, Dietary
  • Potassium