Abstract
A series of quinones (3a-i, 4-9, 11) and aromatic compounds (2a, 2d, 2g) containing the thiophene ring were tested in vitro against the trypomastigote form of Trypanosoma cruzi and the promastigote forms of Leishmania. The quinones 3a-i, 4, 5a, b, 6 and 9 having the thiophene ring fused to a quinone nucleus were the most active members of the series. The electron affinities of the benzo[b]thiophene-4,7-quinones 3, evaluated by their LUMO energies and halfwave potentials, are reported.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / chemical synthesis*
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Antiprotozoal Agents / pharmacology
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Biological Assay
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Chagas Disease / drug therapy
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Chagas Disease / parasitology
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Electron Transport / drug effects
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Leishmania / drug effects
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Leishmania / metabolism
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Mice
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Quinones / chemical synthesis*
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Quinones / pharmacology
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Spectroscopy, Fourier Transform Infrared
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Thiophenes / chemical synthesis*
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Thiophenes / pharmacology
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Trypanosoma cruzi
Substances
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Antiprotozoal Agents
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Quinones
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Thiophenes