Whither goest the RGS proteins?

Crit Rev Biochem Mol Biol. 1999;34(4):215-51. doi: 10.1080/10409239991209273.


Studies of the desensitization of G protein-coupled signal transduction have led to the discovery of a family of guanosine triphosphatase-activating proteins (GAPs) for heterotrimeric G protein alpha subunits - the "regulator of G protein signaling" or RGS proteins. In considering both documented and potential functions of several RGS protein family members with demonstrable multidomain compositions (p115RhoGEF, PDZRhoGEF, Axin, Axil/Conductin, D-AKAP2, the G protein-coupled receptor kinases [GRKs], the DEP/GGL/RGS subfamily [RGS6, RGS7, RGS9, RGS11], and RGS12), this review explores the shift in our appreciation of the RGS proteins from unidimensional desensitizing agents to multifocal signal transduction regulators.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • A Kinase Anchor Proteins
  • Adaptor Proteins, Signal Transducing*
  • Amino Acid Sequence
  • Animals
  • Axin Protein
  • Carrier Proteins / physiology
  • Cell Cycle / physiology
  • Cyclic AMP-Dependent Protein Kinases / physiology
  • Cytoskeletal Proteins / physiology
  • Fungal Proteins / physiology
  • GTP-Binding Proteins / physiology
  • Humans
  • Models, Biological
  • Molecular Sequence Data
  • Protein-Tyrosine Kinases / physiology
  • Proteins / physiology
  • RGS Proteins / metabolism*
  • RGS Proteins / physiology*
  • Repressor Proteins*
  • Sequence Homology, Amino Acid
  • Signal Transduction*
  • rho GTP-Binding Proteins / physiology


  • A Kinase Anchor Proteins
  • AKAP10 protein, human
  • AXIN2 protein, human
  • Adaptor Proteins, Signal Transducing
  • Axin Protein
  • Carrier Proteins
  • Cytoskeletal Proteins
  • Fungal Proteins
  • Proteins
  • RGS Proteins
  • Repressor Proteins
  • Protein-Tyrosine Kinases
  • Cyclic AMP-Dependent Protein Kinases
  • GTP-Binding Proteins
  • rho GTP-Binding Proteins