Spirochetal infection of the nervous system

Neurol Clin. 1999 Nov;17(4):783-800. doi: 10.1016/s0733-8619(05)70166-3.


Neurologic infection is a characteristic feature of spirochetes. The neurologic manifestations of spirochetal infection are a source of continuing public concern: Lyme neuroborreliosis in endemic areas, neurosyphilis in HIV infected patients, and neuroborreliosis during outbreaks of relapsing fever. These are reviewed in this article. The techniques for diagnosis and recommendations in the management of these infections are also discussed.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Humans
  • Spirochaetales Infections / cerebrospinal fluid
  • Spirochaetales Infections / diagnosis*
  • Spirochaetales Infections / drug therapy


  • Anti-Bacterial Agents