Central nervous system involvement in Rickettsial diseases

Neurol Clin. 1999 Nov;17(4):801-12. doi: 10.1016/s0733-8619(05)70167-5.


The Rickettsia are obligate intracellular parasites that are usually spread to humans by insects and typically produce vasculitides. The prototypic rickettsial disorder in the United States is Rocky Mountain spotted fever (RMSF). The differential diagnosis of RMSF and related disorders includes other conditions that produce vasculitis, most importantly meningococcemia. The rickettsial disorders are usually treated effectively with tetracycline derivatives.

Publication types

  • Review

MeSH terms

  • Central Nervous System Infections / microbiology*
  • Humans
  • Rickettsiaceae Infections / complications*
  • Rickettsiaceae Infections / diagnosis*
  • Rickettsiaceae Infections / drug therapy
  • Rickettsiaceae Infections / epidemiology
  • United States