CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)

FEBS Lett. 1999 Oct 8;459(2):195-9. doi: 10.1016/s0014-5793(99)01251-x.


We have recently cloned a putative chemoattractant receptor, named CRTH2, which is preferentially expressed on human T-helper- (Th) 2 but not Th1 cells. In this study, we demonstrated that CRTH2 is also highly expressed on peripheral blood basophils and eosinophils. Our search for a CRTH2 ligand identified mast cells as the possible producers of a ligand. When stimulated with an anti-FcepsilonR1 antibody, cord blood-derived mast cells secreted factor(s) that induced Ca(2+) mobilization in CRTH2-expressing K562 cells but not in mock transfected cells. These findings implied the involvement of CRTH2 in mast cell-mediated immune responses such as allergic reactions.

MeSH terms

  • Basophils / metabolism*
  • Calcium / metabolism
  • Eosinophils / metabolism*
  • Humans
  • Hypersensitivity / metabolism
  • K562 Cells
  • Ligands
  • Mast Cells / metabolism*
  • Receptors, Immunologic / biosynthesis*
  • Receptors, Prostaglandin*
  • Stem Cell Factor / metabolism*
  • Th2 Cells / metabolism*


  • Ligands
  • Receptors, Immunologic
  • Receptors, Prostaglandin
  • Stem Cell Factor
  • Calcium
  • prostaglandin D2 receptor