Polymorphism in the tumor necrosis factor B gene is associated with Palmoplantar pustulosis

Tissue Antigens. 1999 Sep;54(3):288-90. doi: 10.1034/j.1399-0039.1999.540312.x.


We investigated the allele and genotype distribution of a polymorphism of the tumor necrosis factor (TNF) B gene and the frequency of HLA-DR9 in 49 patients with Palmoplantar pustulosis (PPP) and 51 healthy controls. We found that the frequency of TNFB2 in the PPP patients was significantly higher than that in the controls. Furthermore, the DR9-TNFB2 haplotype was significantly more frequent in the PPP patients (P=0.0045). These results suggest that TNFB2 may confer susceptibility to PPP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Genotype
  • Humans
  • Lymphotoxin-alpha / genetics*
  • Polymorphism, Genetic / genetics*
  • Psoriasis / genetics*


  • Lymphotoxin-alpha