Design and interpretation of vaccine field studies

Epidemiol Rev. 1999;21(1):73-88. doi: 10.1093/oxfordjournals.epirev.a017990.


There are many different effects to consider when evaluating vaccines in the field. In this review, we have covered some of the various measures and issues related to study design and interpretation of the different measures. We emphasize that in designing and understanding vaccine studies, it is necessary to be specific about what the effect of interest is and about the assumptions underlying the interpretation of the results. Halloran et al. (81) present design, analysis, and interpretation of vaccine studies in more detail.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Disease Transmission, Infectious
  • Epidemiologic Research Design
  • Humans
  • Immunization Programs*
  • Safety
  • Statistics as Topic
  • Vaccination
  • Vaccines*


  • Vaccines