Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin

Lancet. 1999 Oct 9;354(9186):1266-7. doi: 10.1016/S0140-6736(99)04271-3.

Abstract

Two patients with chloracne had concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of 144,000 and 26,000 pg/g blood lipids. Olestra, a non-digestible, lipophilic dietary fat substitute accelerated the patients' intestinal excretion of TCDD by eight to ten fold. This is sufficient to reduce the normally observed elimination half life of TCDD from about 7 years to 1-2 years.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acne Vulgaris / blood
  • Acne Vulgaris / chemically induced
  • Acne Vulgaris / drug therapy*
  • Adult
  • Body Burden
  • Dietary Fats / administration & dosage
  • Dietary Fats / therapeutic use*
  • Dose-Response Relationship, Drug
  • Environmental Pollutants / adverse effects*
  • Environmental Pollutants / blood*
  • Environmental Pollutants / pharmacokinetics
  • Fatty Acids / administration & dosage
  • Fatty Acids / therapeutic use*
  • Feces / chemistry
  • Female
  • Half-Life
  • Humans
  • Metabolic Clearance Rate
  • Polychlorinated Dibenzodioxins / adverse effects*
  • Polychlorinated Dibenzodioxins / blood*
  • Polychlorinated Dibenzodioxins / chemistry
  • Polychlorinated Dibenzodioxins / pharmacokinetics
  • Sucrose / administration & dosage
  • Sucrose / analogs & derivatives*
  • Sucrose / therapeutic use

Substances

  • Dietary Fats
  • Environmental Pollutants
  • Fatty Acids
  • Polychlorinated Dibenzodioxins
  • Sucrose
  • sucrose polyester