A case of sporadic Pick disease with onset at 27 years

Arch Neurol. 1999 Oct;56(10):1289-91. doi: 10.1001/archneur.56.10.1289.


Background: Pick disease is an uncommon cause of dementia in middle age, and young-onset cases have rarely been reported.

Setting: A specialist hospital.

Patient: Patient with onset of cognitive impairment at the age of 27 years whose cerebral biopsy specimen demonstrated Pick cells and tau-positive Pick bodies.

Conclusion: Pick disease should be considered in the differential diagnosis of dementia in young adults.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Atrophy
  • Cytoplasm / pathology
  • Dementia / pathology*
  • Diagnosis, Differential
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Neurons / pathology
  • Pick Disease of the Brain / pathology*