A complete genome screen in sib pairs affected by Gilles de la Tourette syndrome. The Tourette Syndrome Association International Consortium for Genetics

Am J Hum Genet. 1999 Nov;65(5):1428-36. doi: 10.1086/302613.

Abstract

Gilles de la Tourette syndrome is a neuropsychiatric disorder characterized by waxing and waning multiple motor and phonic tics with a complex mode of inheritance. Previous attempts, which used large multigenerational families to localize susceptibility loci, have been unsuccessful. In this report, the results of the first systematic genome scan, using 76 affected-sib-pair families with a total of 110 sib pairs, are summarized. While no results reached acceptable statistical significance, the multipoint maximum-likelihood scores (MLS) for two regions (4q and 8p) were suggestive (MLS > 2.0). Four additional genomic regions also gave multipoint MLS scores between 1.0 and 2.0.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Female
  • Genetic Markers
  • Genetic Testing*
  • Genome, Human
  • Genotype
  • Humans
  • Likelihood Functions
  • Male
  • Nuclear Family*
  • Obsessive-Compulsive Disorder / genetics
  • Phenotype
  • Tourette Syndrome / diagnosis
  • Tourette Syndrome / genetics*

Substances

  • Genetic Markers