Neurogenesis in the neocortex of adult primates

Science. 1999 Oct 15;286(5439):548-52. doi: 10.1126/science.286.5439.548.

Abstract

In primates, prefrontal, inferior temporal, and posterior parietal cortex are important for cognitive function. It is shown that in adult macaques, new neurons are added to these three neocortical association areas, but not to a primary sensory area (striate cortex). The new neurons appeared to originate in the subventricular zone and to migrate through the white matter to the neocortex, where they extended axons. These new neurons, which are continually added in adulthood, may play a role in the functions of association neocortex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging
  • Animals
  • Astrocytes / cytology
  • Axons / ultrastructure
  • Bromodeoxyuridine
  • Cell Differentiation
  • Cell Division
  • Cell Movement
  • Cell Survival
  • Female
  • Lateral Ventricles / cytology
  • Macaca fascicularis
  • Male
  • Microscopy, Confocal
  • Neocortex / cytology*
  • Neocortex / physiology
  • Neurons / cytology*
  • Neurons / physiology
  • Parietal Lobe / cytology*
  • Parietal Lobe / physiology
  • Prefrontal Cortex / cytology*
  • Prefrontal Cortex / physiology
  • Temporal Lobe / cytology*
  • Temporal Lobe / physiology
  • Visual Cortex / cytology
  • Visual Cortex / physiology

Substances

  • Bromodeoxyuridine