Regulation of E2F: a family of transcription factors involved in proliferation control

Gene. 1999 Sep 17;237(2):281-302. doi: 10.1016/s0378-1119(99)00305-4.

Abstract

Members of the E2F family of transcription factors are key participants in orchestration of the cell cycle, cell growth arrest and apoptosis. Therefore, an understanding of the regulation of E2F activity is essential for an understanding of the control of cellular proliferation. E2F activity is regulated by the retinoblastoma family of tumor suppressors and by multiple other mechanisms. This review will describe our current knowledge of these mechanisms which together constitute a highly complex network by which the cell cycle and cellular proliferation can be controlled.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Carrier Proteins*
  • Cell Cycle / physiology
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / physiology
  • Cell Division / physiology
  • DNA-Binding Proteins*
  • E2F Transcription Factors
  • Gene Expression Regulation
  • Humans
  • Retinoblastoma-Binding Protein 1
  • Transcription Factor DP1
  • Transcription Factors / genetics*
  • Transcription Factors / physiology

Substances

  • Carrier Proteins
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • Retinoblastoma-Binding Protein 1
  • Transcription Factor DP1
  • Transcription Factors