Fish oil reduces gastric acid secretion

Scand J Gastroenterol. 1999 Sep;34(9):845-8. doi: 10.1080/003655299750025282.

Abstract

Background: The aim of the present investigation was to study gastric acid secretion and release of gastrin, cholecystokinin (CCK), and secretin during intraduodenal perfusion of either fish oil or trioleate.

Methods: Seven healthy volunteers were stimulated on two separate days in random order with intraduodenal perfusates of either fish oil or trioleate.

Results: Intravenous infusion with gastrin-17 was used as a background stimulation in doses mimicking a postprandial situation (39.9 +/- 4.8 pmol/l fish oil and 43.6 +/- 3.8 pmol/l trioleate). Gastric acid secretion increased significantly from a basal level of 0.7 +/- 0.1 meq/15 min to 4.0 +/- 0.6 meq/15 min (P < 0.05) before perfusion of fish oil, which reduced gastric acid secretion to 1.9 +/- 0.4 meq/15 min (P < 0.01). After termination of fish oil perfusion gastric acid secretion increased to preperfusion concentrations (P < 0.01). Perfusion of trioleate did not influence gastric acid secretion. Plasma concentrations of CCK rose significantly during perfusion of fish oil (from 2.8 +/- 0.6 pmol/l to 4.4 +/- 0.7pmol/l, P<0.01), whereas trioleate only tended to increase CCK concentrations. Plasma concentrations of secretin did not change during perfusion of fish oil; however, concentrations were significantly lower during and after perfusion of trioleate (P < 0.01).

Conclusion: The present study shows that intraduodenal perfusion of fish oil is associated with a significant reduction of the gastric acid secretion stimulated by gastrin in healthy humans.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cholecystokinin / blood
  • Cholecystokinin / metabolism
  • Duodenum
  • Female
  • Fish Oils / administration & dosage
  • Fish Oils / pharmacology*
  • Gastric Acid / metabolism*
  • Gastrins / administration & dosage
  • Gastrins / blood
  • Gastrins / metabolism
  • Humans
  • Male
  • Perfusion
  • Secretin / blood
  • Secretin / metabolism
  • Statistics, Nonparametric
  • Triolein / administration & dosage
  • Triolein / pharmacology*

Substances

  • Fish Oils
  • Gastrins
  • Triolein
  • Secretin
  • Cholecystokinin