Clinical and MRI findings in spinocerebellar ataxia type 5

Neurology. 1999 Oct 12;53(6):1355-7. doi: 10.1212/wnl.53.6.1355.


Spinocerebellar ataxia type 5 (SCA5), one of the genetically heterogeneous autosomal dominant cerebellar ataxias, was assigned to chromosome 11 in a single family descending from the grandparents of President Abraham Lincoln. We report a second, apparently unrelated, SCA5 family of French origin. The overall clinical picture was a slowly progressive cerebellar syndrome beginning mostly in the third decade (27+/-10 years, range 14 to 40). MRI showed a marked global cerebellar atrophy similar to SCA6.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Genetic Linkage
  • Genetic Markers
  • Genotype
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Pedigree
  • Spinocerebellar Ataxias / genetics*
  • Spinocerebellar Ataxias / pathology*


  • Genetic Markers