Effects of OspA vaccination on Lyme disease serologic testing

J Clin Microbiol. 1999 Nov;37(11):3718-21. doi: 10.1128/JCM.37.11.3718-3721.1999.

Abstract

This study presents the effects of OspA vaccination on two-step testing for Borrelia burgdorferi antibodies. Although vaccinees developed enzyme-linked immunosorbent assay reactivity, immunoblots did not fulfill Centers for Disease Control and Prevention criteria for positivity. Furthermore, OspA reactivity did not interfere with interpretation of immunoblots with sera from patients who developed early Lyme disease despite vaccination.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase II

MeSH terms

  • Adult
  • Antibodies, Bacterial / blood
  • Antigens, Surface / immunology*
  • Bacterial Outer Membrane Proteins / immunology*
  • Bacterial Vaccines / pharmacology*
  • Borrelia burgdorferi Group / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Immunoblotting
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Lipoproteins*
  • Lyme Disease / diagnosis*
  • Lyme Disease / immunology*
  • Lyme Disease / prevention & control
  • Serologic Tests
  • Vaccination

Substances

  • Antibodies, Bacterial
  • Antigens, Surface
  • Bacterial Outer Membrane Proteins
  • Bacterial Vaccines
  • Immunoglobulin G
  • Immunoglobulin M
  • Lipoproteins
  • OspA protein