The histopathology of coeliac disease: time for a standardized report scheme for pathologists

Eur J Gastroenterol Hepatol. 1999 Oct;11(10):1185-94. doi: 10.1097/00042737-199910000-00019.


In this paper, we review the histological features of coeliac disease and propose a standardized report scheme based on the Marsh classification. Furthermore, terms used by pathologists are defined. The most important histological differential diagnoses are given, as well as a definition of the different clinical forms of coeliac disease such as symptomatic, silent, latent, potential, treated and refractory coeliac disease.

Publication types

  • Review

MeSH terms

  • Biopsy
  • Celiac Disease / classification
  • Celiac Disease / diagnosis*
  • Celiac Disease / immunology
  • Celiac Disease / pathology*
  • Diagnosis, Differential
  • Disease Progression
  • Glutens / immunology
  • Humans
  • Intestinal Mucosa / pathology
  • Intestine, Small / pathology
  • T-Lymphocytes / immunology
  • Terminology as Topic


  • Glutens