Clinical and prognostic categorization of extraintestinal nontyphoidal Salmonella infections in infants and children

Clin Infect Dis. 1999 Nov;29(5):1151-6. doi: 10.1086/313469.


The study included 172 patients, aged 0-15 years, for whom at least 1 nonfecal, nonurinary specimen was culture-positive for nontyphoidal Salmonella. Ninety-five percent had positive blood cultures. Immunocompromising diseases were found in 19% of 74 infants and 77% of 98 children. Associations between the study factors and outcomes, as localized infection or death, were assessed by logistic regression analysis. Thirty-three patients had localized infections. An adjusted risk factor for development of localized infections was an age of <12 months (P=.003). There were 17 deaths. The case-fatality rates were 43% and 10% for immunocompromised and 5% and 0% for nonimmunocompromised infants and children, respectively. Adjusted risk factors for death were age of <12 months (P=.006), inappropriate antimicrobial therapy (P=.014), meningitis or culture-proven pneumonia due to nontyphoidal Salmonella (P=.004), and immunocompromised status (P<.001). The clinical courses and prognoses for infants and children with extraintestinal infection due to nontyphoidal Salmonella can be categorized into 4 groups according to the characteristics of age (infants vs. children) and host status (immunocompromised vs. nonimmunocompromised).

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Diarrhea / etiology
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Leukocyte Count
  • Male
  • Multivariate Analysis
  • Prognosis
  • Risk Factors
  • Salmonella Infections / immunology
  • Salmonella Infections / mortality*