FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

Cytokine. 1999 Oct;11(10):729-35. doi: 10.1006/cyto.1999.0485.

Abstract

We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis-pseudoglioma syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line.

MeSH terms

  • Adenocarcinoma
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Division
  • Cell Line
  • Chromosomes, Human, Pair 11 / genetics
  • Cloning, Molecular
  • Colorectal Neoplasms
  • Fibroblast Growth Factors / chemistry
  • Fibroblast Growth Factors / genetics*
  • Fibroblast Growth Factors / metabolism*
  • Gene Expression
  • Heparin / pharmacology
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • Physical Chromosome Mapping
  • Protein Binding / drug effects
  • Protein Sorting Signals
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Receptor, Fibroblast Growth Factor, Type 4
  • Receptors, Fibroblast Growth Factor / genetics
  • Receptors, Fibroblast Growth Factor / metabolism*
  • Recombinant Fusion Proteins / chemistry
  • Recombinant Fusion Proteins / metabolism
  • Retina / embryology
  • Retina / metabolism
  • Sequence Alignment
  • Syndrome
  • Tumor Cells, Cultured

Substances

  • FGF19 protein, human
  • Protein Sorting Signals
  • RNA, Messenger
  • Receptors, Fibroblast Growth Factor
  • Recombinant Fusion Proteins
  • Fibroblast Growth Factors
  • Heparin
  • FGFR4 protein, human
  • Receptor, Fibroblast Growth Factor, Type 4

Associated data

  • GENBANK/AF110400