Abstract
Osteoarthritis involves the degeneration of articular cartilage together with changes in subchondral bone and limited intra-articular inflammation. In this chapter these changes are reviewed at the tissue, cell and molecular levels to reveal the complexity of a process which involves multiple changes in joint structure and turnover.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Biomarkers / analysis
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Body Fluids / chemistry
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Bone Remodeling
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Bone and Bones / pathology
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Bone and Bones / physiopathology
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Cartilage, Articular / enzymology
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Cartilage, Articular / metabolism
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Cartilage, Articular / pathology
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Cartilage, Articular / physiopathology
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Extracellular Matrix / metabolism
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Gene Expression
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Humans
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Inflammation / pathology
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Metalloendopeptidases / metabolism
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Osteoarthritis / metabolism
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Osteoarthritis / pathology*
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Osteoarthritis / physiopathology*
Substances
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Biomarkers
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Metalloendopeptidases