An introduction to the pathophysiology of osteoarthritis

Front Biosci. 1999 Oct 15:4:D662-70. doi: 10.2741/poole.

Abstract

Osteoarthritis involves the degeneration of articular cartilage together with changes in subchondral bone and limited intra-articular inflammation. In this chapter these changes are reviewed at the tissue, cell and molecular levels to reveal the complexity of a process which involves multiple changes in joint structure and turnover.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biomarkers / analysis
  • Body Fluids / chemistry
  • Bone Remodeling
  • Bone and Bones / pathology
  • Bone and Bones / physiopathology
  • Cartilage, Articular / enzymology
  • Cartilage, Articular / metabolism
  • Cartilage, Articular / pathology
  • Cartilage, Articular / physiopathology
  • Extracellular Matrix / metabolism
  • Gene Expression
  • Humans
  • Inflammation / pathology
  • Metalloendopeptidases / metabolism
  • Osteoarthritis / metabolism
  • Osteoarthritis / pathology*
  • Osteoarthritis / physiopathology*

Substances

  • Biomarkers
  • Metalloendopeptidases