Acute motor axonal neuropathy and acute motor-sensory axonal neuropathy share a common immunological profile

J Neurol Sci. 1999 Oct 15;168(2):121-6. doi: 10.1016/s0022-510x(99)00180-x.


Griffin and colleagues (Griffin JW, Li CY, Ho TW, Tian M, Gao CY, Xue P, Mishu B, Cornblath DR, Macko C, McKhann GM, Asbury AK. Pathology of motor-sensory axonal Guillain-Barré syndrome. Ann Neurol 1996;39:17-28 [4]) proposed that acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN) are part of the spectrum of a single type of immune attack on the axon. In contrast, IgG anti-GM1 antibody is associated closely with AMAN, but whether other IgG anti-ganglioside antibodies are associated with this neuropathy is not clear. We investigated whether IgG anti-ganglioside antibodies can be used as immunological markers to differentiate AMAN from acute inflammatory demyelinating polyneuropathy (AIDP) and whether these autoantibodies are present in AMSAN. The frequencies of anti-GM1, anti-GM1b, and anti-GD1a IgG antibodies in 21 AMAN patients were significantly higher than in 19 AIDP patients. Anti-GM1b and anti-GD1a IgG, as well as anti-GM1 IgG antibodies, therefore are immunological markers for AMAN. The patients with AMSAN had anti-GM1, anti-GM1b, and anti-GD1a IgG antibodies, indicative that AMAN and AMSAN share a common immunological profile.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Bacterial / blood
  • Autoantibodies / blood
  • Campylobacter jejuni / immunology
  • Child
  • Female
  • G(M1) Ganglioside / analogs & derivatives
  • G(M1) Ganglioside / immunology
  • Gangliosides / immunology
  • Guillain-Barre Syndrome / classification*
  • Guillain-Barre Syndrome / diagnosis
  • Guillain-Barre Syndrome / immunology*
  • Guillain-Barre Syndrome / microbiology
  • Guillain-Barre Syndrome / physiopathology
  • Humans
  • Immunoglobulin G / blood
  • Male
  • Middle Aged
  • Neural Conduction / physiology
  • Predictive Value of Tests


  • Antibodies, Bacterial
  • Autoantibodies
  • Gangliosides
  • Immunoglobulin G
  • ganglioside, GD1a
  • G(M1) Ganglioside
  • ganglioside M1b