As Chlamydomonas reinhardtii acclimates to low-CO2 conditions there is an increase in cyclophilin expression

Plant Mol Biol. 1999 Aug;40(6):1055-62. doi: 10.1023/a:1006262123918.


When exposed to low CO2 levels, Chlamydomonas reinhardtii acquires the ability to accumulate CO2 to increase photosynthetic carbon fixation. A cDNA library has been constructed and screened to facilitate the identification of the different genes and proteins involved in this acclimation to low-CO2 conditions. The differential cDNA library screening led to the identification of several cDNAs up-regulated under low-CO2 conditions. One such cDNA shows homology to cyclophilins, a class of immunophilins with a peptidyl-prolyl cis-trans isomerase activity. This is the first report of an algal cyclophilin. In this report we study the changes in the C. reinhardtii cyclophilin transcript and protein levels during low-CO2 adaptation. Possible reasons for the increased cyclophilin expression in response to the drop in CO2 concentration are discussed.

MeSH terms

  • Adaptation, Physiological / drug effects
  • Adaptation, Physiological / genetics
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Carbon Dioxide / pharmacology*
  • Chlamydomonas reinhardtii / enzymology
  • Chlamydomonas reinhardtii / genetics*
  • Cloning, Molecular
  • DNA, Complementary / chemistry
  • DNA, Complementary / genetics
  • Gene Expression Regulation, Enzymologic / drug effects
  • Molecular Sequence Data
  • Peptidylprolyl Isomerase / genetics*
  • RNA / drug effects
  • RNA / genetics
  • RNA / metabolism
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Time Factors


  • DNA, Complementary
  • Carbon Dioxide
  • RNA
  • Peptidylprolyl Isomerase

Associated data

  • GENBANK/AF052206