Stem Cells. 1999;17(5):306-13. doi: 10.1002/stem.170306.


Mechanisms in Hematology is a book with an accompanying interactive CD-ROM designed to assemble basic concepts that underlie clinical understanding and progress. It is presented as a concise text with a series of diagrams that distill diffuse information into a compact form. The interactive CD, in particular, brings many of the processes "to life" as details of the more complex pathways are conveyed in clear visual images. The text begins with the basic molecular biology that underlies hematological and oncological physiology/pathology-cell signaling, adhesion molecules, and apoptosis. This is followed by sections, among others, on hematopoiesis, iron, B12, and folate metabolism, neutrophil function, immunoproteins, chemotherapy, and coagulation. With the permission of the authors and publisher, Stem Cells has reproduced the section on apoptosis, which we think our readers will enjoy.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / physiopathology
  • Animals
  • Apoptosis / physiology*
  • Caspases / physiology
  • Communicable Diseases / physiopathology
  • Hematopoietic Stem Cells
  • Humans
  • Ligands
  • Neoplasms / pathology
  • Neoplasms / physiopathology
  • Neurodegenerative Diseases / physiopathology
  • Proto-Oncogene Proteins c-bcl-2 / physiology
  • Tumor Suppressor Protein p53 / physiology
  • fas Receptor / physiology


  • Ligands
  • Proto-Oncogene Proteins c-bcl-2
  • Tumor Suppressor Protein p53
  • fas Receptor
  • Caspases