Inhibition of triiodothyronine production by fenugreek seed extract in mice and rats

Pharmacol Res. 1999 Nov;40(5):405-9. doi: 10.1006/phrs.1999.0510.


The effects of fenugreek seed extract on the alterations in serum thyroid hormone concentrations were studied in adult male mice and rats. Simultaneously, hepatic lipid peroxidation (LPO) and the activities of the antioxidant enzymes, viz superoxide dismutase (SOD) and catalase (CAT) were examined. Administration of methi seed extract (0.11 g kg body wt.(-1) day(-1) for 15 days) to both mice and rats significantly decreases serum triiodothyronine (T(3)) concentration and T(3)/T(4) ratio, but increases thyroxine (T(4)) levels and body weight. While hepatic LPO and CAT activities were not altered, a significant decrease in SOD activity was observed in both the animal models. These findings suggest that fenugreek seed extract induced inhibition in T(4)to T(3) conversion is not peroxidation-mediated and the inhibition in SOD activity could be the result of a decrease in the protein anabolic hormone, T3.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Catalase / metabolism
  • Depression, Chemical
  • Lipid Peroxidation / drug effects
  • Liver / drug effects
  • Liver / enzymology
  • Liver / metabolism
  • Male
  • Mice
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plants, Medicinal / chemistry*
  • Rats
  • Rats, Wistar
  • Seeds / chemistry
  • Superoxide Dismutase / metabolism
  • Thyroxine / metabolism
  • Trigonella
  • Triiodothyronine / biosynthesis*


  • Plant Extracts
  • Triiodothyronine
  • fenugreek seed meal
  • Catalase
  • Superoxide Dismutase
  • Thyroxine