Molecular cloning of a novel Xenopus spalt gene (Xsal-3)

Biochem Biophys Res Commun. 1999 Oct 14;264(1):151-6. doi: 10.1006/bbrc.1999.1479.


The sal (spalt) gene family is characterized by unique double zinc finger motifs and is conserved among various species from Drosophila to humans. Here we report a new Xenopus member of this family, Xsal-3. It is 38% homologous at the amino acid level to the previously reported Xenopus homologue of the spalt gene, Xsal-1. Alternatively spliced Xsal-3 transcripts give rise to RNAs coding either two or three double zinc fingers, and the longer form is expressed maternally. Xsal-3 is expressed in the neural tube, the mandibular, hyoid, and branchial arch, and the pronephric duct, which is different from the expression pattern of Xsal-1. These findings suggest that Xsal-3 may have distinct roles in early Xenopus development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing
  • Amino Acid Sequence
  • Animals
  • Carrier Proteins / chemistry
  • Carrier Proteins / genetics*
  • Central Nervous System / embryology
  • Central Nervous System / metabolism
  • Cloning, Molecular
  • Embryo, Nonmammalian / metabolism
  • Intracellular Signaling Peptides and Proteins
  • Mandibular Nerve / embryology
  • Mandibular Nerve / metabolism
  • Molecular Sequence Data
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Homology, Amino Acid
  • Xenopus
  • Xenopus Proteins*
  • Zinc Fingers*


  • Carrier Proteins
  • Intracellular Signaling Peptides and Proteins
  • Nerve Tissue Proteins
  • SALL3 protein, Xenopus
  • Xenopus Proteins

Associated data

  • GENBANK/AB030827
  • GENBANK/AB030828