Allograft bone (i.e., bone that is obtained from a donor) implantation is used for bone replacement and for reconstructing serious bone defects during total joint revision surgery. It is also used for bone replacement after large excisions of bone tumors. An extensive variety of laboratory tests must be completed, appropriate storage facilities for allograft bone have to be available, and protocols must be developed before a facility can set up a bone bank. Many ethical issues and nursing responsibilities need to be considered before the decision is made to use allograft bone.