Pharmacological agents acting at subtypes of metabotropic glutamate receptors

Neuropharmacology. 1999 Oct;38(10):1431-76. doi: 10.1016/s0028-3908(99)00092-1.


Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a recognized, but still relatively new area of excitatory amino acid research. Current understanding of the roles and involvement of mGlu receptor subtypes in physiological/pathophysiological functions of the central nervous system has been recently propelled by the emergence of various structurally novel, potent, and mGlu receptor selective pharmacological agents. This article reviews the evolution of pharmacological agents that have been reported to target mGlu receptors, with a focus on the known receptor subtype selectivities of current agents.

Publication types

  • Review

MeSH terms

  • Animals
  • Excitatory Amino Acid Agonists / pharmacology*
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Humans
  • Receptors, Metabotropic Glutamate / drug effects*
  • Receptors, Metabotropic Glutamate / physiology*
  • Recombinant Proteins / drug effects
  • Recombinant Proteins / metabolism


  • Excitatory Amino Acid Agonists
  • Excitatory Amino Acid Antagonists
  • Receptors, Metabotropic Glutamate
  • Recombinant Proteins