Cancer biology: extracellular proteinases in malignancy

Curr Biol. 1999 Oct 21;9(20):R776-8. doi: 10.1016/S0960-9822(00)80011-1.

Abstract

Secreted, matrix-degrading proteinases have been viewed as contributing to tumor metastasis. A recent study indicates that the gene for one of these enzymes, the matrix metalloproteinase stromelysin-1, can actually cause cancer when expressed in transgenic mice.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression
  • Matrix Metalloproteinase 3 / genetics
  • Matrix Metalloproteinase 3 / metabolism
  • Matrix Metalloproteinases / genetics
  • Matrix Metalloproteinases / metabolism*
  • Mice
  • Mice, Transgenic
  • Neoplasms, Experimental / enzymology*
  • Neoplasms, Experimental / genetics
  • Oncogenes

Substances

  • Matrix Metalloproteinases
  • Matrix Metalloproteinase 3