Coronary artery disease in potential lung transplant recipients > 50 years old: the role of coronary intervention

Chest. 1999 Oct;116(4):874-9. doi: 10.1378/chest.116.4.874.


Study objectives: To review the experience of the Alfred Hospital in the systematic assessment of coronary artery disease (CAD) using coronary angiography (CA), and the subsequent management of CAD, in potential lung transplant recipients.

Design: Retrospective study.

Setting: The Alfred Hospital Lung and Heart Transplant Service.

Patients: CAD risk factors were sought in potential recipients of lung transplantation (LTx) who were > 50 years old, including a history of smoking, male gender, hypertension, diabetes, hypercholesterolemia, angina, and a family history of CAD. When feasible, and in the presence of more than one cardiac risk factor, CA was performed.

Results: From 243 referral patients who were > 50 years old, 97 were listed for LTx, and 77 underwent LTx. Four patients were refused LTx on the basis of CAD. Of 101 patients undergoing a detailed cardiac assessment for LTx, 83 had smoked, 56 were male, 48 had hypercholesterolemia, 22 had hypertension, 4 had diabetes, and 3 had a history consistent with angina. Eighty-five patients underwent CA. In 32 cases, CA revealed CAD, and half of these cases were significant stenoses. Eight patients who were assessed required intervention. Five patients of this group have been transplanted; of these, three patients underwent coronary artery grafting at the time of LTx, and two patients underwent preoperative angioplasty or stenting. Only one of these five patients died < 90 days postoperatively.

Conclusion: Significant CAD is a common finding in older patients who are presenting for LTx. Coronary revascularization for severe large vessel stenoses can allow safe LTx. CAD risk factors may predict who should undergo CA, but further studies of clinical and noninvasive assessments of CAD are needed if CA is to be safely avoided in patients at low risk of CAD.

MeSH terms

  • Combined Modality Therapy
  • Coronary Disease / mortality
  • Coronary Disease / therapy*
  • Female
  • Humans
  • Lung Transplantation* / mortality
  • Lung Transplantation* / physiology
  • Male
  • Middle Aged
  • Myocardial Revascularization*
  • Prognosis
  • Risk Factors
  • Survival Rate
  • Victoria