Advanced heart block as a manifestation of a paraneoplastic syndrome from malignant thymoma

Chest. 1999 Oct;116(4):1135-6. doi: 10.1378/chest.116.4.1135.


Malignant thymoma is a rare tumor that is associated with paraneoplastic syndrome. Myocarditis as a paraneoplastic syndrome has been rarely described. Reported herein is a young male patient with malignant thymoma and myocarditis as part of a paraneoplastic syndrome. This resulted in high-degree heart block and an asystolic cardiac arrest despite placement of a permanent pacemaker.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Diagnosis, Differential
  • Fatal Outcome
  • Heart Arrest / etiology
  • Heart Block / diagnosis*
  • Humans
  • Male
  • Myocarditis / diagnosis
  • Pacemaker, Artificial
  • Paraneoplastic Syndromes / diagnosis*
  • Thymoma / diagnosis*
  • Thymus Neoplasms / diagnosis*