To treat the patients with a headache (HA) and with the signs of muscular-articular disorders in a cranio-cervical region a complex physioreflexotherapeutic approach was applied. It was directed to the relaxation of pericranial muscles, to the restoration of a physiologic mobility in a zone of cranio-cervical transition and to the action to the irritative zones of these regions. 60 patients with a headache of tension (HAT) and 48 ones with migraine (M) were treated. A therapy included laser and manual physioreflexotherapy and an education to the muscular autorelaxation technique. An estimation after 6 months of therapy gave good and excellent results in 61% of the patients with HAT and in 37% of the patients with M. A number of the days with HA, a duration and an intensity of the attacks decreased. A conclusion was made that the disorders of craniocervical structures may make worse a course of HA. In such cases there was indicated a described therapeutic approach.