The influence of ozone therapy (parenteral and local application of ozonized solutions) and conventionally used methods of treatment on spectrum dynamics of peripheral blood proteins of 59 patients with phlegmon of the face and the neck was studied. Application of ozone in combined treatment of the given pathology was found to contribute to correction of protein synthetic liver function. Manifested by the rise in albumin level and by decrease in globulin synthesis activity. The effect is explained by hepatocyte metabolism change because of activation of enzymatic intracellular processes.