A practical approach to gout. Current management of an 'old' disease

Postgrad Med. 1999 Oct 1;106(4):115-6, 119-23. doi: 10.3810/pgm.1999.10.1.706.

Abstract

Gouty arthritis is the culmination of a number of physiologic mechanisms that ultimately result in deposition of uric acid within joints and soft tissues. Decreased uric acid clearance through the kidney is the most common cause of gout. Tophaceous gout occurs in less than 10% of patients. Acute episodes are treated with NSAIDs or colchicine. Low-dose therapy with these agents can also prevent recurrent attacks. Most patients with gout need long-term treatment with either uricosuric agents or xanthine oxidase inhibitors.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Arthritis, Gouty / drug therapy*
  • Arthritis, Gouty / etiology
  • Colchicine / therapeutic use
  • Glucocorticoids / therapeutic use
  • Humans
  • Uricosuric Agents / therapeutic use
  • Xanthine Oxidase / antagonists & inhibitors

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Glucocorticoids
  • Uricosuric Agents
  • Xanthine Oxidase
  • Colchicine