Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine

Lancet. 1999 Oct 16;354(9187):1353-4. doi: 10.1016/S0140-6736(98)05860-7.


Diets containing genetically modified (GM) potatoes expressing the lectin Galanthus nivalis agglutinin (GNA) had variable effects on different parts of the rat gastrointestinal tract. Some effects, such as the proliferation of the gastric mucosa, were mainly due to the expression of the GNA transgene. However, other parts of the construct or the genetic transformation (or both) could also have contributed to the overall biological effects of the GNA-GM potatoes, particularly on the small intestine and caecum.

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cooking
  • Diet
  • Galanthus
  • Gastric Mucosa / cytology
  • Gastric Mucosa / drug effects
  • Genetic Engineering*
  • Intestine, Small / drug effects*
  • Intestine, Small / metabolism
  • Lectins / genetics
  • Lectins / metabolism
  • Lectins / pharmacology*
  • Mannose-Binding Lectins*
  • Plant Lectins
  • Rats
  • Solanum tuberosum / chemistry
  • Solanum tuberosum / genetics*


  • Lectins
  • Mannose-Binding Lectins
  • Plant Lectins
  • snowdrop lectin