Analysis of the treatment of basilar skull fractures with and without antibiotics

J Neurosurg. 1975 Dec;43(6):721-6. doi: 10.3171/jns.1975.43.6.0721.


The efficacy of chemoprophylaxis in the treatment of basilar skull fractures was studied in 129 patients over a 2-year period; antibiotics were found ineffective in preventing central nervous system infections, and in some cases may have proved harmful. It is suggested that a more rational approach to the treatment of basilar skull fractures includes close observation of the patient for early signs of meningitis, and if these should develop, treatment with antibiotics appropriate to the organism involved.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Ampicillin / therapeutic use
  • Anti-Bacterial Agents / therapeutic use*
  • Brain Abscess / prevention & control
  • Cephalothin / therapeutic use
  • Humans
  • Meningitis / prevention & control
  • Nasopharynx / microbiology
  • Occipital Bone / injuries*
  • Prospective Studies
  • Retrospective Studies
  • Skull Fractures / complications
  • Skull Fractures / drug therapy*


  • Anti-Bacterial Agents
  • Ampicillin
  • Cephalothin