Outcome of de novo hepatitis C virus infection in heart transplant recipients

Hepatology. 1999 Nov;30(5):1293-8. doi: 10.1002/hep.510300519.


The outcome of de novo hepatitis C virus (HCV) infection in heart transplant recipients of HCV-antibody positive organs is not known. The aim of the study was to determine the short-term outcome of de novo HCV infection in recipients of HCV-positive donor organs. HCV-antibody negative recipients of HCV-antibody positive hearts were identified from January 1, 1991 to February 28, 1998. Control patients matched for year of transplantation were also identified. Twenty-eight patients (22 males, mean age of 56 +/- 11 SD) received hearts from HCV-antibody-positive donors. The control group was similar to the patients in all clinical and demographic aspects. Twenty-three patients had detectable viremia by reverse-transcription polymerase chain reaction (RT-PCR). Of these 23 patients with de novo HCV infection, 7 (30%) developed HCV-related liver disease. Three patients (13%) had chronic hepatitis and 4 patients (17%) developed severe acute cholestatic hepatitis (ACH). Mycophenolate mofetil (MMF) use (P =.04) and high viral load at onset of acute liver disease (P =.02) were associated with ACH. Overall survival was similar between patients with de novo HCV infection and controls (P =.20). Development of ACH (P =.02) and MMF use (P =.0009) were associated with decreased survival in patients with de novo HCV infection. The present study showed that survival of patients with de novo HCV infection was similar to a matched control group. HCV-related severe ACH is associated with a poor short-term outcome in patients with de novo HCV infection. MMF use may be associated with a higher incidence of HCV-related severe ACH and a poor short-term outcome.

MeSH terms

  • Actuarial Analysis
  • Databases as Topic
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Heart Transplantation / mortality
  • Heart Transplantation / physiology*
  • Hepatitis C / mortality
  • Hepatitis C / pathology
  • Hepatitis C / transmission*
  • Hepatitis C Antibodies / blood*
  • Humans
  • Liver Diseases / mortality
  • Liver Diseases / pathology
  • Liver Diseases / virology
  • Liver Function Tests
  • Male
  • Middle Aged
  • Postoperative Complications / virology*
  • Retrospective Studies
  • Survival Analysis
  • Tissue Donors*


  • Hepatitis C Antibodies