Novel Fluorescent Probes for Singlet Oxygen

Angew Chem Int Ed Engl. 1999 Oct 4;38(19):2899-2901. doi: 10.1002/(sici)1521-3773(19991004)38:19<2899::aid-anie2899>3.0.co;2-m.

Abstract

The first fluorescent chemical traps for (1)O(2) have been developed. DPAXs react specifically with (1)O(2) to yield the corresponding endoperoxides, DPAX-EPs (see scheme; X = H, Cl, F). DPAXs scarcely fluoresce, while DPAX-EPs are strongly fluorescent. Since the fluorescence of these probes is unaffected by H(2)O(2), superoxide, and nitric oxide, they are useful for the selective detection of (1)O(2) in biological systems.