Behavioural recovery following striatal transplantation: effects of postoperative training and P-zone volume

Exp Brain Res. 1999 Oct;128(4):535-8. doi: 10.1007/s002210050877.


Rats were trained on an operant task and then received striatal lesions and grafts. Grafts were derived either from whole-ganglionic eminences or restricted to the lateral eminence. When retested 4 months later; graft-associated behavioural recovery was only apparent with extensive retesting. There was no difference in performance between rats that received whole-dissection or lateral-dissection grafts, and no correlation between performance and the amount of striatal-like (P-zone) tissue within the graft. It is suggested that P-zone reconstruction may be necessary, but not sufficient for behavioural recovery, which may additionally depend upon rehabilitative training.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Tissue Transplantation / physiology*
  • Conditioning, Operant / physiology*
  • Corpus Striatum / physiology*
  • Corpus Striatum / transplantation*
  • Fetal Tissue Transplantation
  • Functional Laterality
  • Learning / physiology*
  • Male
  • Rats
  • Reaction Time
  • Time Factors