Abstract
The HAP1 gene encodes a complex transcriptional regulator of many genes involved in electron-transfer reactions and is essential in anaerobic or heme-depleted conditions. We show here that strains derived from S288c carry a defective Ty1 element inserted in the 3' region of the HAP1 ORF. This mutant allele acts as a HAP1 null allele in terms of cytochrome c expression and CYC1 UAS1-dependent transcription, but is able to sustain limited growth in heme-depleted conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cytochrome c Group / metabolism
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Fungal Proteins / genetics*
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Fungal Proteins / metabolism
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Gene Expression Regulation, Fungal
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Mutagenesis, Insertional
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Retroelements
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins*
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Trans-Activators / genetics*
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Trans-Activators / metabolism
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Transcription Factors
Substances
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Cytochrome c Group
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DNA-Binding Proteins
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Fungal Proteins
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HAP1 protein, S cerevisiae
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Retroelements
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Saccharomyces cerevisiae Proteins
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Trans-Activators
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Transcription Factors