Signaling Mechanism of the AT2 Angiotensin II Receptor: Crosstalk between AT1 and AT2 Receptors in Cell Growth

Trends Endocrinol Metab. 1999 Dec;10(10):391-396. doi: 10.1016/s1043-2760(99)00191-5.


The peptide angiotensin (Ang) II exerts a range of actions in the cardiovascular, renal, reproductive and central nervous systems. At least two distinct Ang II receptor subtypes have been defined and designated as type 1 (AT1) and type 2 (AT2). The function and signaling mechanism of these receptor subtypes are quite different, and these receptors exert opposite effects on cell growth.