Mechanisms of Glucocorticoid-receptor-mediated Repression of Gene Expression

JC Webster; JA Cidlowski

doi:10.1016/s1043-2760(99)00186-1

Mechanisms of Glucocorticoid-receptor-mediated Repression of Gene Expression

Trends Endocrinol Metab. 1999 Dec;10(10):396-402. doi: 10.1016/s1043-2760(99)00186-1.

Authors

JC Webster¹, JA Cidlowski

Affiliation

¹ Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

PMID: 10542396
DOI: 10.1016/s1043-2760(99)00186-1

Abstract

It is hoped that this review will give the reader a taste of some of the mechanisms used by the glucocorticoid receptor to repress gene function. These mechanisms include direct binding to DNA, antagonism of other transcription factor families and sequestration of necessary cofactors. Each of these mechanisms, and others, are discussed.