How membrane proteins travel across the mitochondrial intermembrane space

Trends Biochem Sci. 1999 Nov;24(11):428-32. doi: 10.1016/s0968-0004(99)01462-0.


A newly discovered family of small proteins in the yeast mitochondrial intermembrane space mediates import of hydrophobic proteins from the cytoplasm into the inner membrane. Loss of one of these chaperone-like proteins from human mitochondria results in a disease that causes deafness, muscle weakness and blindness.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Transport
  • Humans
  • Intracellular Membranes / metabolism*
  • Membrane Proteins / metabolism*
  • Mitochondria / metabolism*
  • Mitochondria / pathology
  • Molecular Chaperones / chemistry
  • Molecular Chaperones / genetics
  • Molecular Chaperones / metabolism*
  • Molecular Sequence Data
  • Syndrome


  • Membrane Proteins
  • Molecular Chaperones