The Economics of Ribosome Biosynthesis in Yeast

Trends Biochem Sci. 1999 Nov;24(11):437-40. doi: 10.1016/s0968-0004(99)01460-7.

Abstract

In a rapidly growing yeast cell, 60% of total transcription is devoted to ribosomal RNA, and 50% of RNA polymerase II transcription and 90% of mRNA splicing are devoted to ribosomal proteins (RPs). Coordinate regulation of the approximately 150 rRNA genes and 137 RP genes that make such prodigious use of resources is essential for the economy of the cell. This is entrusted to a number of signal transduction pathways that can abruptly induce or silence the ribosomal genes, leading to major implications for the expression of other genes as well.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Cycle / genetics
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Fungal Proteins / biosynthesis
  • Fungal Proteins / genetics
  • Gene Expression Regulation, Fungal*
  • Genes, rRNA / genetics
  • Ribosomal Proteins / biosynthesis
  • Ribosomal Proteins / genetics
  • Ribosomes / chemistry
  • Ribosomes / genetics*
  • Ribosomes / metabolism*
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism*
  • Transcription, Genetic / genetics

Substances

  • DNA-Binding Proteins
  • Fungal Proteins
  • Ribosomal Proteins