Clinical and therapeutic properties of Cushing's disease in childhood

Pediatr Neurosurg. 1999 Jul;31(1):12-5. doi: 10.1159/000028825.

Abstract

Cushing's disease (CD) in adolescence and childhood is a rare pathology and has some different clinical and therapeutic characteristics than in adults. We report 3 cases treated surgically, with the diagnosis of CD. Their common complaints were short stature and obesity. Endocrinological investigations and radiological evaluation pointed out the diagnosis of CD for all children. They were operated on by the transsphenoidal route, and adenoma resection was performed. Histopathologic and immunohistochemical examination of the tissue specimens confirmed the diagnosis of CD. Long-term follow-up demonstrated weight loss and increase in height.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / complications
  • Adenoma / diagnostic imaging
  • Adenoma / surgery
  • Adolescent
  • Adrenocorticotropic Hormone / blood
  • Cushing Syndrome / blood
  • Cushing Syndrome / diagnosis*
  • Cushing Syndrome / etiology
  • Cushing Syndrome / surgery
  • Female
  • Growth Disorders / diagnosis
  • Humans
  • Hydrocortisone / blood
  • Male
  • Obesity / diagnosis
  • Pituitary Neoplasms / complications
  • Pituitary Neoplasms / diagnostic imaging
  • Pituitary Neoplasms / surgery
  • Puberty, Delayed / diagnosis
  • Tomography, X-Ray Computed

Substances

  • Adrenocorticotropic Hormone
  • Hydrocortisone